evidence_review
Pepti Review: NAD+ in Three Routes, Including One You Swallow
Pepti prices NAD+ by injection, nasal spray and capsule — $179, $219 and $159 a month. The capsule is not the oral route the human trials studied.
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CoreAge Rx
From $93/mo
Doctor-reviewed NAD+ at the lowest advertised starting price here, with human support included.
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Telos Rx
Intranasal NAD+ & recovery peptides
See Telos RxPepti (hellopepti.com) sells NAD+ three ways and publishes a price for each: $179 a month for the injection, $219 for the nasal spray, $159 for a capsule.1 Every figure is flat — the same monthly price at every dose — and cancelable at the end of a cycle with no minimum term. Among the six operators we read in August 2026, it is the only one offering all three routes at once, which makes it the cleanest place to see something this category keeps blurring.
The capsule is the reason this review exists.
The three rungs
// Pepti's NAD+ menu
| // Route | Per month | Strength published? | Human PK study of the route |
|---|---|---|---|
| Injection | $179 | No | None published |
| Nasal spray | $219 | No | None published |
| Capsule | $159 | No | None published |
We pulled these from the site's own JavaScript bundle rather than from a marketing page, because Pepti renders as a single-page app and its catalog lives in the code. Where Pepti publishes both a subscription price and a one-time price for an item, the one-time figure is the monthly one times 1.25 — we checked that on four separate products and it held each time. It does not publish a one-time figure for any of the three NAD+ rungs, so neither do we.
The nasal rung is the dearest of the three, which is worth flagging because it is also the dearest nasal NAD+ we track — Auren Rx's four nasal options run $169 to $249 depending on strength and bottle size, and Pepti's single $219 spray is quoted without a strength or a volume attached to it anywhere we could find. You cannot work out what a milliliter costs, so you cannot compare it to anything.
The capsule is not the oral route the trials studied
This is the part a product page will not tell you, and it is the single most useful thing on this page.
When this site says the oral route has human data behind it, it means the precursors. Nicotinamide riboside is orally bioavailable and raises blood NAD+ in people, reliably and dose-dependently.23 Oral NMN does the same in controlled trials.45 Those molecules are small, they survive the gut, and there is a published pharmacokinetic record showing what happens after you swallow them.
A capsule of NAD+ itself is a different proposition. NAD+ is a dinucleotide of about 663 Daltons,6 and we could find no published human pharmacokinetic study of swallowing it intact — not for Pepti's capsule and not for anyone else's. The oral NAD+ literature people cite is precursor literature. The two get sold under the same word.
So the $159 capsule is not a cheaper way to get the thing the trials tested. It is a third unmeasured route sitting next to two other unmeasured routes, and the fact that it costs less than the injection tells you about a price list rather than about absorption. Our route-by-route breakdown works through why the bioavailability ranking people repeat does not survive contact with the outcome data.
What stands behind the other two routes
Nothing you have not read here before, and it is worth being exact.
For injected NAD+, there is no randomized human trial and no published pharmacokinetic study. The one human study of administered NAD+ is a small pilot using a six-hour intravenous infusion, and it measured the plasma and urine metabolome rather than any clinical outcome.7 Injection is not IV, and the IV literature stops there. The injection evidence file has the full account.
For intranasal NAD+, the supporting studies are rodent models of stroke and traumatic brain injury.89 They are real experiments and they are not evidence that a spray raises NAD+ in a healthy adult; nose-to-brain delivery remains an open research problem rather than a solved one.10 See can it absorb through the nose.
Even where the biomarker does move, the outcomes are the weak part: a systematic review of precursor trials found metabolic effects limited and inconsistent despite NAD+ rising.11 Three routes at three prices is a wider menu, not a stronger case.
// What stands behind each rung on this menu
- Injected NAD+ raises blood NAD+ in people[ NONE ]
No published human pharmacokinetic study of the subcutaneous route.
- Intranasal NAD+ in people[ NONE ]
Supporting work is rodent stroke and traumatic brain injury models.
- Swallowed NAD+ as the intact dinucleotide[ NONE ]
No published human pharmacokinetic study of oral NAD+ itself, at 663 Da.
- Oral NR and oral NMN raise blood NAD+ (different molecules, sold elsewhere)[ STRONG ]
Reliable and dose-dependent in controlled human trials.
- Raised NAD+ producing energy, focus or anti-aging benefit[ WEAK ]
Limited and inconsistent across precursor trials.
The catalog is enormous, and that is a finding
Sixty-eight prescription items, extracted from the bundle. NAD+ sits inside a shelf that also carries semaglutide, tirzepatide, BPC-157, sermorelin, tesamorelin, epithalon, MOTS-c, SS-31, PT-141, semax, selank, synapsin, methylene blue, oxytocin, kisspeptin, estradiol, clomiphene, hydroquinone and at-home blood panels.
Three of those items should be named plainly, because a reader arriving for NAD+ will see them in the same navigation: retatrutide, melanotan II and IGF-1 LR3. Retatrutide has no FDA approval in any form or jurisdiction. None of the three is something this publication would put in front of a reader as a recommendable option, and their presence on a menu is a fact about the operator's judgment, not a footnote.
The company is explicit that it does not sell research-use-only compounds and that everything is prescribed by a licensed clinician. That is a meaningful distinction from the gray-market peptide sellers this brand name sits close to. It is not the same as a short catalog.
What the site contradicts about itself
Three, and they matter in different ways.
Where it operates. Four separate surfaces — a shipping page, a state-availability page, a providers page and the homepage title — say 36 states, and the list is published. The terms of service say the services are available in 50. Four corroborating surfaces beat one line in a legal document, so we treat 36 as the real number, but you should check your own state on the published list rather than on the terms.
When you are charged. The how-it-works page says you pay nothing until a physician approves your treatment. The refund policy says payment is collected at checkout, before the provider reviews your intake. The refund policy governs, so assume you are charged first and refunded if you are declined — five to ten business days, per the same document.
A price ladder that renders nowhere. Pepti's GLP-1 pages ship a per-dose price array in their production data — roughly three times the flat headline — that no component on the site consumes. We could not reach a checkout to break the tie, because the checkout endpoint accepts no GET request. This is a weight-loss artifact rather than a NAD+ one, and we record it here anyway: a published price and a charged price are the same thing only until they are not, and this is a site where a second set of numbers is demonstrably sitting in production.
Who is behind it
No pharmacy is named. The site describes independent FDA-registered 503A or 503B compounding pharmacies without naming a facility. For a compounded product, where sterility and dosing accuracy live entirely with the compounder, that is the disclosure that matters most and it is absent.
Two prescribers are named, with real bios and no NPIs. A medical director, board-certified in family medicine and licensed in twenty-six named states, and a chief medical officer in internal medicine licensed in fifteen. Education and board certifications are published. Neither NPI is, so neither can be verified against the national registry — which is the difference between a credential and a claim, and the exact line The Edit crosses with a published NPI that resolves.
The corporate entity is pepti LLC at a Newark, Delaware suite that is a well-known registered-agent address rather than an operating site. Its certification seal resolves against the certifying body's own image host. Cancellation is any time, effective at the end of the cycle, with a pause of up to ninety days available and no proration.
The regulatory screen
The trading name and the legal entity both returned zero company-column matches in the FDA's live warning-letter index when we screened them in August 2026.12 The screen carried a positive control — an unrelated telehealth seller with a letter on the record — which returned correctly, so the zero is a result and not a query that failed quietly.
The neighborhood is worth a sentence, because it cuts in Pepti's favor. A search on the stem of its name returns dozens of letters to peptide sellers. Pepti is not among them, and being absent from a list your own brand name puts you next to is a better result than it sounds.
Where it lands
If you want to try more than one NAD+ route without signing up to two companies, this is the only menu in the batch that lets you, and the prices are published, flat across doses and honestly labeled as monthly. That is real.
What you are buying is three unmeasured delivery routes, one of which — the capsule — is sold under a word that belongs to a different molecule with actual human data behind it. The unnamed pharmacy and the unverifiable prescribers are a worse disclosure record than The Edit's named pharmacy and resolving NPI, and the missing strength on the nasal rung means the dearest option here cannot be compared with anything. If your question is how to raise NAD+ for the least money on the most evidence, the answer is still an oral precursor — is nicotinamide riboside worth it and NMN vs NR work through it — and it is not sold here. Providers we do have a commercial relationship with are ranked and disclosed on our NAD+ rankings hub; where the rest of the market sits is on the NAD+ price index.
Frequently asked questions
How much does NAD+ cost at Pepti?
Three routes, all flat monthly prices that do not change with dose, read in August 2026: $179 a month for the injection, $219 for the nasal spray and $159 for the capsule. No strength or volume is published for any of the three, so none of them can be compared per milligram against another seller. Cancellation takes effect at the end of the billing cycle, with no minimum term and no proration.
Is Pepti's oral NAD+ capsule the same as an NMN or NR supplement?
No, and the distinction is the most important thing on this page. NR and NMN are precursors — small molecules with published human pharmacokinetic trials showing they survive the gut and raise blood NAD+. Pepti's capsule is NAD+ itself, a roughly 663-Dalton dinucleotide, and we could find no published human pharmacokinetic study of swallowing it intact. The word 'oral' covers both products and tells you nothing about which one has data behind it.
Which states does Pepti serve?
Thirty-six, and the list is published. Four separate surfaces on the site — its shipping page, its state-availability page, its providers page and its homepage title — all say 36 and agree on the list. Its terms of service say 50. We treat the four corroborating surfaces as the real answer and recommend checking your own state against the published list rather than the terms.
Does Pepti name its pharmacy?
No. It describes independent FDA-registered 503A or 503B compounding pharmacies without naming a facility. Two prescribers are named with full bios, education and board certifications, but neither publishes an NPI, so neither credential can be verified against the national provider registry. For a compounded product, where sterility and dosing accuracy sit with the compounder, the unnamed pharmacy is the bigger gap.
When does Pepti charge you?
Its refund policy says payment is collected at checkout, before a licensed provider reviews your intake; its how-it-works page says you pay nothing until a physician approves treatment. Those contradict each other, and the refund policy is the operative document — so assume you are charged first, with a full refund in five to ten business days if you are declined. There is no refund once medication has shipped.
References
- Pepti (2026). NAD+, peptide and GLP-1 product pricing. hellopepti.com. https://hellopepti.com/
- Trammell SAJ, Schmidt MS, Weidemann BJ, et al. (2016). Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature Communications. https://pubmed.ncbi.nlm.nih.gov/27721479/
- Martens CR, Denman BA, Mazzo MR, et al. (2018). Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications. https://pubmed.ncbi.nlm.nih.gov/29599478/
- Okabe K, Yaku K, Uchida Y, et al. (2022). Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects. Frontiers in Nutrition. https://pubmed.ncbi.nlm.nih.gov/35479740/
- Irie J, Inagaki E, Fujita M, et al. (2020). Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men. Endocrine Journal. https://pubmed.ncbi.nlm.nih.gov/31685720/
- Covarrubias AJ, Perrone R, Grozio A, Verdin E (2021). NAD+ metabolism and its roles in cellular processes during ageing. Nature Reviews Molecular Cell Biology. https://pubmed.ncbi.nlm.nih.gov/33353981/
- Grant R, Berg J, Mestayer R, et al. (2019). A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+. Frontiers in Aging Neuroscience. https://pubmed.ncbi.nlm.nih.gov/31572171/
- Ying W, Wei G, Wang D, et al. (2007). Intranasal administration with NAD+ profoundly decreases brain injury in a rat model of transient focal ischemia. Frontiers in Bioscience. https://pubmed.ncbi.nlm.nih.gov/17127275/
- Won SJ, Choi BY, Yoo BH, et al. (2012). Prevention of traumatic brain injury-induced neuron death by intranasal delivery of nicotinamide adenine dinucleotide. Journal of Neurotrauma. https://pubmed.ncbi.nlm.nih.gov/22352983/
- Agrawal M, Saraf S, Saraf S, et al. (2018). Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs. Journal of Controlled Release. https://pubmed.ncbi.nlm.nih.gov/29772289/
- Oliveira-Cruz A, Macedo-Silva A, Silva-Lima D, et al. (2024). Effects of Supplementation with NAD+ Precursors on Metabolic Syndrome Parameters: A Systematic Review and Meta-Analysis. Hormone and Metabolic Research. https://pubmed.ncbi.nlm.nih.gov/39111741/
- U.S. Food and Drug Administration (2026). Warning Letters. FDA.gov. https://www.fda.gov/inspections-compliance-enforcement-and-criminal-investigations/compliance-actions-and-activities/warning-letters
Medical disclaimer: This content is for general educational purposes only and is not medical advice, diagnosis, or treatment. Always consult a licensed healthcare professional before starting, stopping, or changing any treatment.
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